USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: K1C18_HUMAN USC-OGP 2-DE database:  K1C18_HUMAN K1C18_HUMAN General information about the entry View entry in simple text format Entry name K1C18_HUMAN Primary accession number P05783 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Keratin, type I cytoskeletal 18; AltName: Full=Cell proliferation-inducing gene 46 protein; AltName: Full=Cytokeratin-18; Short=CK-18; AltName: Full=Keratin-18; Short=K18;. Gene name Name=KRT18 Synonyms=CYK18 ORFNames=PIG46 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1175: pI=6.62; Mw=45030 SPOT OGP-1181: pI=5.40; Mw=44276 SPOT OGP-1185: pI=6.07; Mw=43048 SPOT OGP-1189: pI=5.12; Mw=42209 Cross-references UniProtKB/Swiss-Prot P05783; K1C18_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name K1C18_HUMAN Primary accession number P05783 Secondary accession number(s) Q53G38 Q5U0N8 Q9BW26 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Keratin, type I cytoskeletal 18; AltName: Full=Cell proliferation-inducing gene 46 protein; AltName: Full=Cytokeratin-18; Short=CK-18; AltName: Full=Keratin-18; Short=K18; Gene name Name=KRT18 Synonyms=CYK18 ORFNames=PIG46 Encoded on Name=KRT18; Synonyms=CYK18; ORFNames=PIG46 Keywords Acetylation; Cell cycle; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycoprotein; Host-virus interaction; Intermediate filament; Isopeptide bond; Keratin; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X12881; CAA31375.1; -; mRNA EMBL AY762101; AAX07828.1; -; mRNA EMBL BT019412; AAV38219.1; -; mRNA EMBL AK223093; BAD96813.1; -; mRNA EMBL BC000180; AAH00180.1; -; mRNA EMBL BC000698; AAH00698.1; -; mRNA EMBL BC004253; AAH04253.1; -; mRNA EMBL BC008636; AAH08636.1; -; mRNA EMBL BC020982; AAH20982.1; -; mRNA EMBL BC072017; AAH72017.1; -; mRNA EMBL AF179904; AAA59461.1; -; Genomic_DNA EMBL X12883; CAA31377.1; -; mRNA EMBL X12876; CAA31369.1; -; mRNA CCDS CCDS31809.1; -; . PIR S05481; S05481; . RefSeq NP_000215.1; NM_000224.2; . RefSeq NP_954657.1; NM_199187.1; . UniGene Hs.406013; -; . ProteinModelPortal P05783; -; . SMR P05783; -; . BioGrid 110073; 90; . DIP DIP-633N; -; . IntAct P05783; 72; . MINT MINT-215967; -; . STRING 9606.ENSP00000373487; -; . iPTMnet P05783; -; . PhosphoSitePlus P05783; -; . SwissPalm P05783; -; . UniCarbKB P05783; -; . BioMuta KRT18; -; . DMDM 125083; -; . SWISS-2DPAGE P05783; -; . EPD P05783; -; . MaxQB P05783; -; . PaxDb P05783; -; . PeptideAtlas P05783; -; . PRIDE P05783; -; . TopDownProteomics P05783; -; . DNASU 3875; -; . Ensembl ENST00000388835; ENSP00000373487; ENSG00000111057; . Ensembl ENST00000388837; ENSP00000373489; ENSG00000111057; . GeneID 3875; -; . KEGG hsa:3875; -; . UCSC uc001sbe.4; human; . CTD 3875; -; . DisGeNET 3875; -; . GeneCards KRT18; -; . H-InvDB HIX0040371; -; . HGNC HGNC:6430; KRT18; . HPA CAB000008; -; . HPA CAB000030; -; . HPA HPA001605; -; . MalaCards KRT18; -; . MIM 148070; gene; . MIM 215600; phenotype; . neXtProt NX_P05783; -; . OpenTargets ENSG00000111057; -; . PharmGKB PA30217; -; . eggNOG ENOG410IEYR; Eukaryota; . eggNOG ENOG4111DJ8; LUCA; . GeneTree ENSGT00760000119046; -; . HOGENOM HOG000230975; -; . HOVERGEN HBG013015; -; . InParanoid P05783; -; . KO K07604; -; . OMA RAKYEKM; -; . OrthoDB EOG091G0A3U; -; . PhylomeDB P05783; -; . TreeFam TF332742; -; . Reactome R-HSA-6805567; Keratinization; . Reactome R-HSA-6809371; Formation of the cornified envelope; . SignaLink P05783; -; . SIGNOR P05783; -; . ChiTaRS KRT18; human; . GeneWiki Keratin_18; -; . GenomeRNAi 3875; -; . PMAP-CutDB P05783; -; . PRO PR:P05783; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000111057; -; . CleanEx HS_KRT18; -; . ExpressionAtlas P05783; baseline and differential; . Genevisible P05783; HS; . GO GO:0071944; C:cell periphery; IEA:Ensembl; . GO GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL; . GO GO:0034451; C:centriolar satellite; IDA:BHF-UCL; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005882; C:intermediate filament; IDA:BHF-UCL; . GO GO:0045095; C:keratin filament; IDA:UniProtKB; . GO GO:0005815; C:microtubule organizing center; IDA:BHF-UCL; . GO GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0097110; F:scaffold protein binding; IPI:BHF-UCL; . GO GO:0005198; F:structural molecule activity; IEA:InterPro; . GO GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc; . GO GO:0007049; P:cell cycle; IEA:UniProtKB-KW; . GO GO:0070268; P:cornification; TAS:Reactome; . GO GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0043000; P:Golgi to plasma membrane CFTR protein transport; IDA:UniProtKB; . GO GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl; . GO GO:0045104; P:intermediate filament cytoskeleton organization; IDA:UniProtKB; . GO GO:0031424; P:keratinization; TAS:Reactome; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . InterPro IPR001664; IF; . InterPro IPR018039; Intermediate_filament_CS; . InterPro IPR027695; Keratin-18; . InterPro IPR002957; Keratin_I; . PANTHER PTHR23239; PTHR23239; 1; . PANTHER PTHR23239:SF225; PTHR23239:SF225; 1; . Pfam PF00038; Filament; 1; . PRINTS PR01248; TYPE1KERATIN; . SMART SM01391; Filament; 1; . PROSITE PS00226; IF; 1; .

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